CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Chronic Obstructive Pulmonary Disease

We treat chronic lung disease, including chronic obstructive pulmonary disease (COPD), emphysema and chronic bronchitis.

Many of these conditions have no cure, but certain Regenerative medicine treatments can help patients breathe better.

Our treatment harnesses your own natural biological components that can help reduce inflammation in the lungs, regenerate lung structure and induce lung functional recovery through reduction of inflammation, and induction of immunomodulation.

COPD is caused by a combination of small airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema).

The pathophysiology of COPD is mediated primarily by a pathogenic triad: inflammation, oxidative stress, and protease-antiprotease imbalance.

The inflammatory process in the lungs of COPD patients involves concentration of macrophages, neutrophils, CD8+ cytotoxic lymphocytes in the small airways and the subsequent release of humoral factors cytokines, chemokines, and elastolytic enzymes.

Experience our Individually-Center approach for deep regeneration and wellbeing through our leading-edge cellular therapies

Adipose Stem Cell Delivery in COPD

In the case of autologous adipose tissue transfers, many procedures harvest cells from the bone marrow via puncture of the iliac crest, which can increase the risk for infection and considerable pain.

In addition, subcutaneous adipose tissue yields 500 times the amount of cells that bone marrow does. Thus far, most of the procedures in human trials have involved autologous transfers of adipose stem/stromal cells (ASC).

Adipose derived – Mesenchymal Stem cells can differentiate into several different lung cell types such as the alveolar epithelial cells that are destroyed by cigarette smoke leading to emphysematous changes and reduced tethering of small airways causing hyperinflation and gas exchange abnormalities.

Pre-clinical trials in animal models have suggested regeneration of alveolar-like structures, repair of emphysematous lungs, and reduction of inflammatory responses.

Regenerative medicine is now increasingly being used to treat various conditions and COPD is not exempt.

Chronic obstructive pulmonary disease, or COPD, is an umbrella term for chronic conditions that limit airflow in the lungs.

This can cause symptoms like breathlessness and severe coughing, as well as wheezing and chest tightness.

It’s most often caused by pollutants like tobacco smoke and chemicals or fumes. It can also be genetic, meaning you can still develop it even if you don’t have other risk factors. COPD is progressive and requires early treatment to ensure that you can live a healthy lifestyle and avoid limitations.

Can STem Cells Cure my Medical Condition?

When we treat a medical condition, we are just treating the condition, not curing it.

Neither fresh cells nor cultured cells can cure every disease, but they can do great things as far as reducing the severity of symptoms and stopping the advancement of the condition.

Normally, in a lot of chronic degenerative conditions or neurological conditions, several treatments will be needed because the effect of cellular therapies has a time limit.

Our unique approach includes a multi-dose treatment plan, in which we apply the cells once, with follow-ups at three, six, and nine month mark. If symptoms begin to occur, another round of treatment is needed.

What are the different cellular therapies
available for me?

Our comprehensive stem cell treatment protocols employ well-targeted combinations of Exosomes, allogeneic human Mesenchymal cells, and autologous bone marrow and Adipose derived stem cells to treat the diseases and conditions listed previously.

Our treatment plans are mostly focused on a systemic or whole-body approach to ensure these patients receive the highest quality and quantity of cellular products during their time in our hospital.

Of the different kinds of cellular products available for use, there are two main sources that can be used to target the conditions that have been previously discussed.

Autologous procedures

Autologous procedures are those in which the patient is their own donor for the cellular therapy treatment. In these kinds of procedures, a doctor takes a sample (usually of bone marrow or adipose tissue) and harvests the cells from it, before administering it locally to the diseased or damaged area.

Allogeneic procedures

Allogeneic procedures are those in which the patient receives cells that have been sourced from a donor that is not the patient. These samples are neonatal tissue and are comprised of umbilical cord blood.

They are extensively screened to ensure the quality and health of the cells.

The type of treatment used depends on a variety of factors, including medical history and age, but we endeavor to give each patient a personalized, case-by-case treatment plan to ensure that the only possible outcome is a positive one.

Which are the different
administration methods that we use?

After you’ve been selected a candidate, you will meet with our highly-trained team of medical professionals to devise a treatment plan tailored specifically to have the best results possible given your current condition.

Below we will outline the different methods of administering cellular therapies that we use in our medical facilities:

intrathecal-intraarterial

This form of implantation is ideal for neurological conditions because the stem cells are injected past the blood-brain barrier and directly into the spinal fluid, which enables them to reach the spinal cord and brain.

During the procedure, an experienced anesthesiologist inject stem cells into the spinal canal through the lower vertebrae under local anesthesia. They are all performed in a positive airflow room under sterile conditions, and the procedure usually takes about thirty minutes.

Intravenous IV

The safest and simplest method for delivering the stem cells throughout the body.

Anesthesia is not required. We may use Lidocaine topical spray to needle prick area beforehand.

IV administration usually takes about 20 – 30 minutes.

Intramuscular IM

The stem cells are injected directly into the muscle.

Intramuscular implantation is very safe and does not require anesthesia.

What´s Included as part of our treatment?

Before the first day of treatment, we go over the patient’s medical history, including previous and current treatments including physical therapy and cognitive therapy. We interview the patients to know more about them in order to form a custom treatment plan.

Medical General Assessment

Critical care evaluation

Specialist doctor evaluation

Anesthesiology evaluation

Perioperative care

Pharmacy and Supplies

Operating room

Anesthesia Services

Diagnostic/therapeutic imaging

Autologous stem cell acquisition

Pathology services

Hemodynamics suite

Patient coordination fee

Catheterization procedure

Mannitol injection

Med Surg Supplies sterile

Spinal tap procedure

Recovery

Laboratory fee

Culture/Expansion autologous BM
derived stem cells

Med Surg room

IV infusion

Follow up and recommendations

Pick up / Drop off from airport to accommodation and vice versa

Pick up/Drop Off the day of the procedure to and from hospital

The difficulties of pharmacological treatment in some phenotypes of the disease are not able to give an adequate therapeutic response to patients. The bronchodilator drugs and topical steroids are symptomatic and only slow the evolution of lung disease.

Our primary focus of treatment is to reduce the inflammation of the lungs. Usually when the stem cells are administered through an IV, they pass through a pulmonary track which essentially captures the stem cells where they are most needed in the patient’s body.

TREATMENTS:
CHRONIC OBSTRUCTIVE
PULMONARY DISEASE