AUTOIMMUNE DISEASES

Autoimmune diseases are conditions in which the patient’s immune system generates cellular and antibody responses to substances and tissues normally present in the body. This might be restricted to one organ or involve a particular tissue in different places. As a result of this immune response, damage to different organs occurs.

Examples of autoimmune diseases that have responded to stem cell therapy either in animals or humans include rheumatoid arthritis, multiple sclerosis, and lupus. Stem cell therapy has been demonstrated to induce profound healing activity in animals with various forms of autoimmune disorders.

Autoimmune diseases are conditions in which the patient’s immune system generates cellular and antibody responses to substances and tissues normally present in the body. This might be restricted to one organ or involve a particular tissue in different places. As a result of this immune response, damage to different organs occurs.

Examples of autoimmune diseases that have responded to stem cell therapy either in animals or humans include rheumatoid arthritis, multiple sclerosis, and lupus. Stem cell therapy has been demonstrated to induce profound healing activity in animals with various forms of autoimmune disorders.

Stem cells and specifically, mesenchymal stem cells hone to inflamed tissue and start producing anti-inflammatory agents.

These mediators act locally and do not suppress the immune response of the patient’s whole body.

Additionally, mesenchymal stem cells induce the production of T regulatory cells, a type of immune cell whose function is to protect the body against immunological self-attack.

What are the most common autoimmune conditions?

DIABETES TYPE I

Glucose, or sugar, is what your body uses for energy.

When you eat something, your body processes the food into glucose so that it can power your cells. If you have type I diabetes, you most likely experience difficulty with this process.

This is because the immune system mistakenly attacks the pancreas’s insulin-making cells. Insulin is responsible for helping glucose enter your cells from the bloodstream.

When the body doesn’t have enough insulin, the glucose stays in the bloodstream and causes further health problems.

In the context of diabetes research, MSCs have been used to generate insulin-producing cells, counteract autoimmunity enhance islet engraftment and survival, and to treat diabetic ulcers and limb ischemia.

Also, MSC inoculum improved metabolic control in experimental models of type 2 diabetes (T2D). Non-randomized, pilot trials in T2D suggest a positive impact of bone marrow–derived mononuclear cells on metabolic control (i.e., reduction of insulin requirements and of A1C values) in the absence of adverse events following intraarterial injection by selective cannulation of the pancreas vasculature.

Rheumatoid arthritis

Your joints are an elaborate and effective system of tissues that allow you to move.

However, these joints can be subject to an autoimmune response called rheumatoid arthritis.

This condition can cause pain during movement because the linings that help the joint glide and move become swollen.

If the inflammation isn’t treated, it can affect tissues like cartilage or bones, causing further damage to the joints.

THYROID CONDITIONS

The thyroid is an important gland in the neck that is responsible for regulating your body’s metabolism through hormones.

Sometimes, the immune system attacks the thyroid and prevents it from producing enough hormones, a condition called hypothyroidism.

This can cause many different uncomfortable symptoms like fatigue, joint and muscle pain, decreased temperature regulation, and weight gain. Additionally, hyperthyroidism can occur where too many hormones are produced.

LUPUS

Lupus is an extremely complex disease where the immune system attacks areas like the kidneys, lungs, nervous system, and circulatory system.

This can cause many different complications over time, resulting in poor health and many complicated treatment plans.

Many people who experience lupus have it for most of their lives.

FIBROMYALGIA

Fibromyalgia is a chronic condition that causes pain, achiness, and fatigue all over the body.

It occurs because the brain and nervous system misunderstand everyday signals from things like minor pain, pressure, temperature, and other sensory experiences, instead receiving signals as pain instead.

This means fibromyalgia sufferers often have chronic pain all over the body and few relief options.

Can STem Cells Cure my Medical Condition?

When we treat a medical condition, we are just treating the condition, not curing it.

Neither fresh cells nor cultured cells can cure every disease, but they can do great things as far as reducing the severity of symptoms and stopping the advancement of the condition.

Normally, in a lot of chronic degenerative conditions or neurological conditions, several treatments will be needed because the effect of cellular therapies has a time limit.

Our unique approach includes a multi-dose treatment plan, in which we apply the cells once, with follow-ups at three, six, and nine month mark. If symptoms begin to occur, another round of treatment is needed.

What are the different cellular therapies
available for me?

Our comprehensive stem cell treatment protocols employ well-targeted combinations of Exosomes, allogeneic human Mesenchymal cells, and autologous bone marrow and Adipose derived stem cells to treat the diseases and conditions listed previously.

Our treatment plans are mostly focused on a systemic or whole-body approach to ensure these patients receive the highest quality and quantity of cellular products during their time in our hospital.

Of the different kinds of cellular products available for use, there are two main sources that can be used to target the conditions that have been previously discussed.

Autologous procedures

Autologous procedures are those in which the patient is their own donor for the cellular therapy treatment. In these kinds of procedures, a doctor takes a sample (usually of bone marrow or adipose tissue) and harvests the cells from it, before administering it locally to the diseased or damaged area.

Allogeneic procedures

Allogeneic procedures are those in which the patient receives cells that have been sourced from a donor that is not the patient. These samples are neonatal tissue and are comprised of umbilical cord blood.

They are extensively screened to ensure the quality and health of the cells.

The type of treatment used depends on a variety of factors, including medical history and age, but we endeavor to give each patient a personalized, case-by-case treatment plan to ensure that the only possible outcome is a positive one.

Which are the different
administration methods that we use?

After you’ve been selected a candidate, you will meet with our highly-trained team of medical professionals to devise a treatment plan tailored specifically to have the best results possible given your current condition.

Below we will outline the different methods of administering cellular therapies that we use in our medical facilities:

intrathecal-intraarterial

This form of implantation is ideal for neurological conditions because the stem cells are injected past the blood-brain barrier and directly into the spinal fluid, which enables them to reach the spinal cord and brain.

During the procedure, an experienced anesthesiologist inject stem cells into the spinal canal through the lower vertebrae under local anesthesia. They are all performed in a positive airflow room under sterile conditions, and the procedure usually takes about thirty minutes.

Intravenous IV

The safest and simplest method for delivering the stem cells throughout the body.

Anesthesia is not required. We may use Lidocaine topical spray to needle prick area beforehand.

IV administration usually takes about 20 – 30 minutes.

Intramuscular IM

The stem cells are injected directly into the muscle.

Intramuscular implantation is very safe and does not require anesthesia.

What´s Included as part of our treatment?

Before the first day of treatment, we go over the patient’s medical history, including previous and current treatments including physical therapy and cognitive therapy. We interview the patients to know more about them in order to form a custom treatment plan.

Medical General Assessment

Critical care evaluation

Specialist doctor evaluation

Anesthesiology evaluation

Perioperative care

Pharmacy and Supplies

Operating room

Anesthesia Services

Diagnostic/therapeutic imaging

Autologous stem cell acquisition

Pathology services

Hemodynamics suite

Patient coordination fee

Catheterization procedure

Mannitol injection

Med Surg Supplies sterile

Spinal tap procedure

Recovery

Laboratory fee

Culture/Expansion autologous BM
derived stem cells

Med Surg room

IV infusion

Follow up and recommendations

Pick up / Drop off from airport to accommodation and vice versa

Pick up/Drop Off the day of the procedure to and from hospital

Currently, autoimmune conditions are treated with immunosuppressive agents such as steroids, methothrexate, cyclosporine, gold, and more recently infliximab (Remicade).
Despite inducing temporary improvement, these approaches possess the possibility of long-term adverse effects, as well as need for life-long treatment.

Your immune system is highly important in keeping your body healthy and protected against invaders like bacteria and viruses. It includes a complex network of cells, organs, proteins, and tissues that attack and remove harmful organisms.

However, some people are susceptible to autoimmune diseases, where the immune system mistakenly attacks its own body. This can include areas like your joints, skin, organs, or other important functions of the body, causing pain and complications. Autoimmune diseases often have a very large impact on your quality of life, making it difficult to be active and healthy.

Because there are many different autoimmune diseases, it’s difficult to determine what they have in common that makes the immune system misfire. However, some people are more susceptible to autoimmune diseases than others. It’s also common for autoimmune diseases to run in families.

TREATMENTS: AUTOIMMUNE DISEASES