AUTISM

Advancements made in regenerative medicine are swiftly approaching the development of an autism stem cell therapy. This is because stem cell therapy has already been established as an effective approach to many neurological conditions, as well as immunological, musculoskeletal, and physiological disorders and diseases.

Stem cells have a unique ability to influence metabolism and the immune system as well as to restore damaged cells and tissues. These therapies positively affect all body organs and systems, including the most important organ of all — the brain.

Now stem cells are showing great promise for children and adults who need help in combating the symptoms of autism.

While this therapy can be very beneficial, it is not a cure for autism in any way.

The goal of stem cell therapy is to improve patients’ behavior and overall well-being.

Experience our Individually-Center approach for deep regeneration and wellbeing through our leading-edge cellular therapies

Decreasing inflammation in the autistic patient may alleviate symptoms of autism

The treatment of immune deregulation using stem cells in autism, has been shown to not only cause an improvement of intestinal and systemic symptomatology, but also to profoundly influence neurological function.

Numerous reports exist of temporary neurological improvement by decreasing intestinal inflammation through either antibiotic administration or dietary changes.

Although some anti-inflammatory treatments have yielded beneficial effects, no clinical agent has been developed that can profoundly suppress inflammation at the level of the fundamental immune abnormality.

We believe mesenchymal stem cell administration may be used for this purpose.

The rationale behind treating autism with umbilical cord tissue-derived mesenchymal stem cells is that autism, and its degree of severity, has been significantly correlated inflammatory and neuro-inflammatory cytokines including macrophage-derived chemokine (MDC) and thymus and activation-regulated chemokine (TARC).

Intravenous administration of umbilical cord MSCs has been shown in multiple clinical trials to decrease inflammation.

The medications used for treatment often lack evidence of safety and efficacy for the core features of Autism, and instead target maladaptive behaviours and comorbid psychopathology (i.e. irritability, depression, anxiety, hyperactivity and obsessive-compulsive behaviours).

Concerns over safety have limited the availability of approved psychotropic medications for children in general, and have been encouraging the development of biomedical treatments to target specific biological issues or symptoms.

These include the use of: melatonin, acetylcholinesterase inhibitors,naltrexone, carnitine, tetrahydrobiopterin, vitamin C, glutamate antagonists, special dietary supplements, hyperbaric oxygen treatment, immunomodulation and anti-inflammatory treatments, oxytocin, acupuncture, music therapy and vision therapy.

In the midst of these various therapies, stem cell therapies are emerging as the future of molecular and regenerative medicine and they are providing new opportunities for ASD interventions.

An important characteristic of mesenchymal stem cells is their ability to constitutively secrete immune inhibitory factors, this is believed to further allow inhibition of immunity in an antigen specific manner, as well as to allow the use of such cells in an allogeneic fashion without fear of immune-mediated rejection. Antigen immune suppression is believed to allow these cells to shut off autoimmune processes.

Understanding Autism

Autism and autism spectrum disorders (ASDs) are heterogeneous, severe neurodevelopmental disorders with core symptoms of dysfunctions in social interactions and communication skills, restricted interests, repetitive – stereotypic verbal and non-verbal behaviours.

Biomolecular evidence points to complex gene-environmental interactions in ASDs. Several biochemical processes are associated with ASDs: oxidative stress (including endoplasmic reticulum stress), decreased methylation capacity, limited production of glutathione; mitochondrial dysfunction, intestinal dysbiosis, increased toxic metal burden and various immune abnormalities.

Equally, these immune dysregulations serve as the rationale for immune-directed interventions such as hematopoietic stem cells (HSCs), which are pivotal in controlling chronic inflammation and in the restoration of immunological balance. These properties make them potential agents for ASD treatments.

Can STem Cells Cure my Medical Condition?

When we treat a medical condition, we are just treating the condition, not curing it.

Neither fresh cells nor cultured cells can cure every disease, but they can do great things as far as reducing the severity of symptoms and stopping the advancement of the condition.

Normally, in a lot of chronic degenerative conditions or neurological conditions, several treatments will be needed because the effect of cellular therapies has a time limit.

Our unique approach includes a multi-dose treatment plan, in which we apply the cells once, with follow-ups at three, six, and nine month mark. If symptoms begin to occur, another round of treatment is needed.

What are the different cellular therapies
available for me?

Our comprehensive stem cell treatment protocols employ well-targeted combinations of Exosomes, allogeneic human Mesenchymal cells, and autologous bone marrow and Adipose derived stem cells to treat the diseases and conditions listed previously.

Our treatment plans are mostly focused on a systemic or whole-body approach to ensure these patients receive the highest quality and quantity of cellular products during their time in our hospital.

Of the different kinds of cellular products available for use, there are two main sources that can be used to target the conditions that have been previously discussed.

Autologous procedures

Autologous procedures are those in which the patient is their own donor for the cellular therapy treatment. In these kinds of procedures, a doctor takes a sample (usually of bone marrow or adipose tissue) and harvests the cells from it, before administering it locally to the diseased or damaged area.

Allogeneic procedures

Allogeneic procedures are those in which the patient receives cells that have been sourced from a donor that is not the patient. These samples are neonatal tissue and are comprised of umbilical cord blood.

They are extensively screened to ensure the quality and health of the cells.

The type of treatment used depends on a variety of factors, including medical history and age, but we endeavor to give each patient a personalized, case-by-case treatment plan to ensure that the only possible outcome is a positive one.

Which are the different
administration methods that we use?

After you’ve been selected a candidate, you will meet with our highly-trained team of medical professionals to devise a treatment plan tailored specifically to have the best results possible given your current condition.

Below we will outline the different methods of administering cellular therapies that we use in our medical facilities:

intrathecal-intraarterial

This form of implantation is ideal for neurological conditions because the stem cells are injected past the blood-brain barrier and directly into the spinal fluid, which enables them to reach the spinal cord and brain.

During the procedure, an experienced anesthesiologist inject stem cells into the spinal canal through the lower vertebrae under local anesthesia. They are all performed in a positive airflow room under sterile conditions, and the procedure usually takes about thirty minutes.

Intravenous IV

The safest and simplest method for delivering the stem cells throughout the body.

Anesthesia is not required. We may use Lidocaine topical spray to needle prick area beforehand.

IV administration usually takes about 20 – 30 minutes.

Intramuscular IM

The stem cells are injected directly into the muscle.

Intramuscular implantation is very safe and does not require anesthesia.

What´s Included as part of our treatment?

Before the first day of treatment, we go over the patient’s medical history, including previous and current treatments including physical therapy and cognitive therapy. We interview the patients to know more about them in order to form a custom treatment plan.

Medical General Assessment

Critical care evaluation

Specialist doctor evaluation

Anesthesiology evaluation

Perioperative care

Pharmacy and Supplies

Operating room

Anesthesia Services

Diagnostic/therapeutic imaging

Autologous stem cell acquisition

Pathology services

Hemodynamics suite

Patient coordination fee

Catheterization procedure

Mannitol injection

Med Surg Supplies sterile

Spinal tap procedure

Recovery

Laboratory fee

Culture/Expansion autologous BM
derived stem cells

Med Surg room

IV infusion

Follow up and recommendations

Pick up / Drop off from airport to accommodation and vice versa

Pick up/Drop Off the day of the procedure to and from hospital

While stem cell therapy is an extremely safe alternative to many other invasive surgeries and therapies, it is not without its risks. However, these risks can be mitigated by selecting highly-trained, certified experts to perform your procedure.

We take every possible step and procedure to ensure a safe surgery conducted as quickly as can be safely done.

During your consultation, you can bring forward any other questions or expectations with our expert physicians.

TREATMENTS: AUTISM