Regenerative medicine is the exciting cutting-edge “medicine of the future” which holds the hope & the promise of efficacy which revolves around the ability of human tissue to be repaired, replaced, and healed (regenerated) once human tissues and organs are damaged or diseased. Regenerative therapies aid and supplement the natural healing mechanisms of the body. These therapies often employ the activation of stem cells to stimulate renewal of tissue damaged by injury, disease, or age. The rapid expansion of scientific knowledge offers great promise for continuing advances in this field of medicine which holds vast potential to improve the quality of human life.
 
What are stem cells?
Stem cells are the basic building blocks of life. They are unspecialized cells that can produce more stem cells through mitosis or differentiate into specialized cells that carry out specific functions in the body. Stem cells are found throughout the body’s tissues, organs, and systems although usually in small quantities in adults.
 
What are hematopoietic stem cells?
Hematopoietic stem cells (HSCs) can give rise to all types of blood cells including red blood cells, white blood cells, and platelets. They are particularly useful in the treatment of blood-related diseases and conditions.
 
What are mesenchymal stem cells?
Mesenchymal Stem Cells (MSCs) are multipotent stromal cells that are non-blood forming stem cells and can differentiate into a variety of cell types including muscle, bone, cartilage, and fat cells.
 
When introduced into a patient’s body, MSCs can repair or replace damaged or degenerating tissue by communicating with the surrounding cells thus causing a cellular cascade of healing (paracrine signaling).
 
Historically, the term MSC was coined in the late 80’s by the biomedical research authority, Dr. Arnold Caplan of Case Western Reserve. The acronym has recently been redefined by Caplan to “Medicinal Signaling Cell” since these cells secrete powerful bioactive molecules involved in cellular signaling and regeneration. Caplan now describes MSCs as a “multisite-regulatory dispensary” (Natural Drug Store).
 
The production of MSCs in the human body, can be precipitated by bioactive placental tissues containing Growth Factors, Cytokins and other powerful bioactive agents which trigger cell signaling.
 
The remarkable ability of MSCs make them irreplaceable in medical treatments.
 
What are accessible sources of stem cells?
Stem cells can be extracted from various parts of the body. They have been extracted from bone marrow and adipose tissue for a few decades. More recently, birth tissues from live births, including umbilical cord blood, cord tissue, with Wharton’s Jelly, and amniotic membrane tissue, have been found to be a rich source of both HSCs and MSCs and in addition, precipitate target tissue production of MSCs through paracrine signaling. Growth Factors, Cytokins, Exosomes & micro-RNA from birth tissues give rise to Stem cells in this way. These cells, as well as MSCs contained in Wharton’s Jelly tend to be more fit than stem cells obtained from adult stem cells.
 
WHARTON’S JELLY
 
Wharton’s jelly is a gelatinous substance found in the umbilical cord which is rich in stem cells. Studies have shown that mesenchymal stem cells (MSCs) have low immunogenicity. Human umbilical cord Wharton’s jelly provides a new source for MSCs that are highly proliferative and have multi-differentiation potential. Wharton’s Jelly Cells (WJCs) express MSC markers but low levels of human leukocyte antigen (HLA)-ABC and no HLA-DR.  WJCs have low functional  immunogenicity and therefore recipient rejection has not been documented.
 
Advanced Regenerative Medicine
Advanced Regenerative Medicine involves the use of regenerative biomolecules, tissue engineering and stem cells to treat diseased or injured tissues.

We want to talk here about the fascination that stem cells produce over scientists and lay people. Ever since we heard about this microscopic buddies for the first time, we started imagining endless possibilities for treatments and, why not: cures.
So scientists went right to work. One of the objectives was to find ways to control how stems cells develop into other cell types, in the hopes of creating new therapies. The work is on its infancy but,  as we all hear constantly, it is very promising.
Researchers have learned that pluripotent cells—stem cells that have the ability to differentiate into any kind of cell- when cultured in certain types of confined spaces started activating genes that determined the tissue those cells were going to become.  Most of the medical investigation on stem cells has focused on modifying the combination of growth solutions to stimulate differentiation. The cellular surroundings are an important element to controlling how stem cells transform into other cell types. The research continues. and the perspectives are exciting. We have already obtained dopamine producing neurons from pluripotent cells! We have already created a sugar based scaffold of blood vessels!!
Now what happens out of the lab?. Physicians and patients alike have embraced the use of fresh adult stem cells obtained from fat or bone marrow to treat some degenerative conditions. Clinical trials have demonstrated significant improvement, for example in knee osteoarthritis, sports injuries, frozen shoulder etc. What happens in this case? how do these cells work?. Well: adult stem cells not necessarily differentiate or “become” cartilage, or tendon, or muscle. By the release of information, proteins, anti-inflamatory elements; this cells will influence the environment and stimulate the growth and differentiation of the local cells, hence regenerating and healing damaged tissue. So with slight differences what is being achieved in the laboratory, happens in a very natural fashion inside our bodies through the harnessing of our own cells healing power!
Isn’t it all short of amazing?
 
Will see you in the next blog. Keep your cells healthy!

So we have been in the regenerative medicine specialty for about 8 years. Just like pretty much everyone, we started by using Platelet Rich Plasma. We learnt about it, we were fascinated by it and we treated our patients with it. Patients loved and so did we. ‘
PRP, if obtained and used correctly is a very powerful tool to implement in any medical practice. Especially if we deal with the elderly, osteoarthritis, wear and tear of tendons and ligaments, loss of vitality. The PRP is also very frequently used in Plastic and reconstructive surgery. For wound care, scar improvement and overall rejuvenation of the skin.
But why does it work? and how?
Well, we are all familiar with platelets. They seem to have significant power and influence over tissue regeneration, and by concentrating them in a blood sample we can obtain signaling proteins, cytokines and growth factors. If we add white blood cells to the mix, we will have what is called L-PRP (leukocyte rich PRP), which makes that “soup” even more interesting.
Now, to harness the power of those bioactive substances we need to coax the cells into releasing them. Normally the platelets get activated by the addition of calcium, or by contact with collagen. But several studies have demonstrated the influence of laser of low intensity over the activity of some cells. That effect is called “Photobiomodulation”. Basically  it is form of light this modality uses non-ionizing light sources, like LEDs or Helium-Neon lasers to produce photochemical events at various biological scales. It have been demonstrated that this light will react with the enzyme Cytochrome C oxidase which is paramount in the mitocondrial processes.
Several scientists went on to study this light and its effects over cellular cultures. and they found that cells proliferate more when exposed to low level laser, they also showed increased viability!
So we went on to compare the levels of cytokines and growth factors in an irradiated sample and a non irradiated one. And sure enough some of the growth factors even tripled the concentrations after laser exposure. The famous Interleukin 10, anti inflammatory protein doubled the levels, endorfines were released in high levels.
It has been established that the photobiomodulation process will give extraordinary benefits in pain management or inflammation, immunomodulation, and promotion of wound healing and tissue regeneration, and it plays a  fundamental part in our protocols.
 
Isn’t it all short of amazing?
 
Will see you in the next blog. Keep your cells healthy!

Hair loss is very common, with tens of millions, if not hundreds of millions of people all over the world suffering from it. Hundreds of thousands of people decide to utilize hair restoration therapy, as well as other procedures in order to try to get at least some of their former hair back. Although some are effective, most of the time, the treatments only move already existing hair from one place to another. However, with Stem Cell therapy, we try to help new hair grow by helping the follicles to regenerate.
 
Adimarket helps, alongside a few other companies, to help provide new and reliable uses for PRP and stem cell therapies. We provide the equipment and other services so that doctors and practices will be able to provide these services to their patients.
 
There’s a Lot of Promise
 
While the main people talking about PRP and stem cell therapies are smaller companies like us, many other people are also discussing and seeing potential in these therapies. These include doctors, and practices, such as a doctor from Miami known as Lazaro M Garcia Md. This doctor already utilized PRP and stem cell therapy for people who suffer from hair loss, and is currently conducting a study that is supported by the National Institutes of Health.
 
In order to participate in the study, patients pay a small fee, which changes based on what part of the study they are in. Afterwards, the receive 2 injections of PRP and stem cells that are made from their own body, over 3 months.
 
Dr. Garcia is utilizing the body’s own growth factors in order to increase the amount of blood and nutrients to the otherwise dead hair follicles. This makes the dead follicles more lively and allows them to create new hair growth.
 
The way to make Platelet Rich Plasma is to is to use the patients own blood, which can come from either bone marrow, or other sources of fat. They go into a centrifuge, which concentrates the composition, and then allows them to be injected into the treatment site. While it is an otherwise simple procedure, some training in still necessary to ensure that it is done safely.
 
We Provide Equipment
 
We at Adimarket do not perform stem cell and PRP therapies, but we do offer the equipment so that doctors and practices can do so themselves. These include amniotic tissue, stem cell and PRP kits, centrifuge devices, and many more. Practices and doctors can order directly from us.
 
It is good to note that not all PRP systems are equal. The system that we have uses the closed tabletop system that is able to process the PRP in under 10 minutes. For more information, contact us or visit our website.
 
Hair loss is a serious problem with many people suffering from it. Now, thanks for PRP and stem cell therapies, we no longer only have to rely on hair replacement surgery to help patients. PRP and stem cell therapies may be the best therapy out there for both your patients, as well as your practice.

Here at Adimarket, we sell equipment to practices that are willing and able to add PRP and stem cell therapies to their lineup. The equipment we offer is among the best, and we have helped hundreds of doctors and practices to offer PRP and stem cell therapies. However, we also provide marketing services above that as well.
 
Although it might see odd that we offer both marketing services, as well as equipment, but it is not so odd once you understand why. Simply offering services and having the equipment to do so does not in itself help patients to fully know that you are offering new services. It is best practice to get the word out to as many people in the area as possible.
 
While there are many reasons why we do this, here are the three main reasons why.
 
Regenerative Medicine Was Founded Not Too Long Ago 
Compared to many other medical practices, such as surgery and physical therapy, regenerative medicine is still fairly new. In fact, most people do not really know that PRP and stem cell therapy even exists, let alone can be used to manage chronic pain.
 
The fact that not many people even know about the existence of regenerative medicine, let alone what it can be used for, means that it would be difficult to get your patients to even understand what you are offering as a service. This can be addressed with marketing. Through marketing, a practice can not only let it become known that they are offering these new services, but also explain shortly what the service entails.
 
Marketing Is Like Dieting 
Pretty much every doctor and dietitian knows that good nutrition is vital to great health down the line. Waiting until you’re sick and deficient to discuss nutrition is not the best way to address the issue. Marketing is similar in that instance. Marketing not only can be used to keep current patients informed, but can also be used to inform new patients about what you offer. Practices that don’t market often suffer in the same way as people who don’t get good nutrition.
 
There’s a lot of competition 
Medicine has sadly become more and more like a business in the past years. This means that even doctors and practices need to have a good business sense if they are going to continue to be able to provide the type of services that patients need and desire. Not understanding business would only make any practice fail or at least prevent them from growing.
 
Because of this, private practices, as well as other medical groups are forced to compete. Marketing is a big way to make sure that you get patients instead of your competition. If you are utilizing PRP and stem cell therapies as a way to generate more income, then great! However, you will still have to market those services to get the word out, as well as compete.
 
We at Adimarket offer these services as a way to help the field of regenerative marketing succeed. We not only help your practice start to utilize regenerative medicine, but we also help you to promote your practice in the same way. This will help your patients know that you are using these methods, and what they are, so that you can get a leg up over the competition.